Anna Arnqvist - Associate Professor

Mechanisms for stochastic and tightly controlled regulation of H. pylori adhesins

The bacterium H. pylori colonizes the human stomach of more than half of the world’s population. Among the infected, the majority remains non-symptomatic while a minor subpopulation develops severe gastric disease such as peptic ulcer of gastric cancer. Unless treated, H. pylori colonizes the harsh environ in the stomach for the lifetime. Adhesion of H. pylori to the gastric epithelial lining is a key factor for establishment of the lifelong persistent infection. The so far best-studied adhesin is the blood group antigen binding adhesin BabA, which mediate binding to ABO-blood group antigens present in the gastric epithelial lining. Another well-characterized adhesin is the sialic acid binding adhesin, SabA, which mediates binding to the sialyl-Lewis a/x antigens in inflamed gastric mucosa. We have in previous studies described mechanisms that affect adhesin-receptor interactions and in particular mechanisms that affect adhesin expression. With our expertise in H. pylori genetics in combination with biochemical approaches, we seek to continue to unravel the molecular mechanisms that operate to fine-tune expression of the BabA and the SabA adhesins in relation to environmental factors and disease.

H. pylori outer membrane vesicles (OMV) and host cellular responses

We are also interested in outer membrane vesicles that are shedded from the H. pylori bacterial surface, the function of vesicles as vehicles for delivery of bacterial virulence factors and the corresponding host cellular response.

Group:
Pär Johansson, PhD student
Ikenna Obi (PhD), Post Doc
Anna Åberg (PhD), senior research engineer
Anna Vallström (PhD), combined research and medical intern

Publications

Author

Title

Year sorteringsordning

Fulltext

Skoog, Emma C.
Padra, Medea
Åberg, Anna; et al.

BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS
Scientific Reports, 7

2017

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Bugaytsova, Jeanna A.
Björnham, Oscar
Chernov, Yevgen A.; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, 21(3): 376-389

2017

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Moonens, Kristof
Gideonsson, Pär
Subedi, Suresh; et al.

Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Cell Host and Microbe, 19(1): 55-66

2016

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Turkina, Maria V.
Olofsson, Annelie
Magnusson, Karl-Eric; et al.

Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell-cell contacts and induce histone H1 binding to ATP in epithelial cells
FEMS Microbiology Letters, 362(11)

2015

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Olofsson, Annelie
Nygård Skalman, Lars
Obi, Ikenna; et al.

Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways
mBio, 5(3): e00979-14-

2014

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Åberg, Anna
Gideonsson, Pär
Vallström, Anna; et al.

A Repetitive DNA Element Regulates Expression of the Helicobacter pylori Sialic Acid Binding Adhesin by a Rheostat-like Mechanism
PLoS Pathogens, 10(7)

2014

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Ohno, Tomoyuki
Vallström, Anna
Rugge, Massimo; et al.

Effects of blood group antigen-binding adhesin expression during Helicobacter pylori infection of Mongolian gerbils
Journal of Infectious Diseases, 203(5): 726-735

2011

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Basmarke-Wehelie, Rahma
Sjolinder, Hong
Jurkowski, Wiktor; et al.

The Complement Regulator CD46 Is Bactericidal to Helicobacter pylori and Blocks Urease Activity
Gastroenterology, 141(3): 918-928

2011

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Olofsson, Annelie
Vallström, Anna
Petzold, Katja; et al.

Biochemical and functional characterization of Helicobacter pylori vesicles
Molecular Microbiology, 77(6): 1539-1555

2010

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Petzold, Katja
Olofsson, Annelie
Arnqvist, Anna; et al.

Semiconstant-Time P,H-COSY NMR: Analysis of Complex Mixtures of Phospholipids Originating from Helicobacter pylori
Journal of the American Chemical Society, 131(40): 14150-1

2009

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Contact Information

Umeå University
Medical Biochemistry and Biophysics
SE-901 87 Umeå, SWEDEN 

Visiting Address
KBC-building, 6th floor

Tel:  +46 90 786 6539

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