Nasim Sabouri - Assistant Professor

Maintenance of genome integrity by DNA helicases

One of the challenges in cancer biology is to understand what happens when the molecular mechanisms of a normal cell become dysfunctional and cause cancer. Maintaining genome stability during DNA synthesis is critical to prevent diseases. We are studying how genome integrity is preserved and the consequences of modifying the program of DNA replication.

Replication fork movement does not proceed smoothly throughout the genome, but encounters multiple types of impediments. DNA regions that are bound by non-nucleosomal protein complexes and sequences that form secondary DNA structures are known natural impediments to the replication fork. We are using the fission yeast Schizosaccharomyces pombe to study how replication fork is coordinated at natural fork impediments. We aim to elucidate factors that facilitate fork progression to ensure genome stability.

Publications

Author

Title

Year sorteringsordning

Fulltext

Livendahl, Madeleine
Jamroskovic, Jan
Hedenström, Mattias; et al.

Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA
Organic and biomolecular chemistry, 15(15): 3265-3275

2017

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Sabouri, Nasim

The functions of the multi‑tasking Pfh1Pif1 helicase
Current Genetics, 63(4): 621-626

2017

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McDonald, Karin R
Guise, Amanda J
Pourbozorgi-Langroudi, Parham; et al.

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity
PLoS Genetics, 12(9)

2016

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Wallgren, Marcus
Mohammad, Jani B
Yan, Kok-Phen; et al.

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase
Nucleic Acids Research, 44(13): 6213-6231

2016

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Livendahl, Madeleine
Jamroskovic, Jan
Ivanova, Svetlana; et al.

Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Chemistry - A European Journal, 22(37): 13004-13009

2016

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Jamroskovic, Jan
Livendahl, Madeleine
Eriksson, Jonas; et al.

Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool
Chemistry - A European Journal, 22(52): 18932-18943

2016

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McDonald, Karin R
Sabouri, Nasim
Webb, Christopher J; et al.

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening
DNA Repair, 24: 80-86

2014

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Miralles Fusté, Javier
Shi, Yonghong
Wanrooij, Sjoerd; et al.

In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication
PLOS Genetics, 10(12): e1004832-

2014

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Sabouri, Nasim
Capra, John A
Zakian, Virginia A

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
BMC biology, 12(1)

2014

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Sabouri, Nasim
McDonald, Karin R
Webb, Christopher J; et al.

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase
Genes & Development, 26(6): 581-593

2012

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Dr. Nasim Sabouri

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Contact Information

Umeå University
Medical Biochemistry and Biophysics
SE-901 87 Umeå 

Visiting Address
KBC-building, 6th floor

Tel:  +46 90 786 5000

Mobile:  +46 72 566 2505

Fax:  +46 90 786 9795

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