Jürgen Schleucher - Professor

A biophysical approach to study climate change

The publication "Deriving correlated climate and physiological signals from deuterium isotopomers in tree rings." from the Schleucher group has been highlighted on "Faculty of 1000", read the review here: http://f1000biology.com/article/id/1161823/evaluation

Biomolecular Function from Molecular Scale to Global Scale

We study internal motions of nucleic acids and proteins, to establish relations to their biological functions. Examples include: Mobility of intact ribosomes (PNAS 2004, 10949); structure and internal motions of a RNA reverse transcriptase binding site (NAR 2002, 4803). New projects involve function of Helicobacter adhesins, internal motions of DNA and RNA, and folding of an RNA thermosensor.
Methods development includes new isotope labelling schemes (NAR 2002, 1639) and new NMR experiments. The off-resonance ROESY experiment gives qualitatively new insight into internal motions (JACS 2002, 5881), such as internal motions of H,H vectors used in structure calculations, and of intermolecular contacts.

Reflecting metabolic regulation, enzyme isotope effects induce variable distributions of stable heavy isotopes among non-equivalent intramolecular positions of non-symmetrical metabolites. We measure this variation by NMR and deduce metabolic regulation.


Relating to Global Climate Change, we apply this to deuterium in tree rings. We can separate deuterium signals from climate and physiology, and study plant-climate interactions on time scales of centuries. Plant-climate interactions affect both future climate and agricultural productivity, therefore their understanding is crucial for climate prediction and adaptation to Climate Change.

Contact This e-mail address is being protected from spambots. You need JavaScript enabled to view it me for Ph.D. opportunities in:
* biomolecular NMR
* NMR applications in climate change research

Group:
Agnieszka Sadlej (Post Doc)
Ina Ehlers (PhD-student)
Thomas Wieloch (PhD-student)

Publications

Author

Title

Year sorteringsordning

Fulltext

Öquist, Mats G.
Erhagen, Björn
Haei, Mahsa; et al.

The effect of temperature and substrate quality on the carbon use efficiency of saprotrophic decomposition
Plant and Soil, 414(1): 113-125

2017

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Spahr, Stephanie
Bolotin, Jakov
Schleucher, Jürgen; et al.

Compound-specific carbon, nitrogen, and hydrogen isotope analysis of N-nitrosodimethylamine in aqueous solutions
Analytical Chemistry, 87(5): 2916-2924

2015

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Ehlers, Ina
Augusti, Angela
Betson, Tatiana R.; et al.

Detecting long-term metabolic shifts using isotopomers: CO2-driven suppression of photorespiration in C-3 plants over the 20th century
Proceedings of the National Academy of Sciences of the United States of America, 112(51): 15585-15590

2015

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Ehlers, Ina
Betson, Tatiana R.
Vetter, Walter; et al.

Elucidating Turnover Pathways of Bioactive Small Molecules by Isotopomer Analysis: The Persistent Organic Pollutant DDT
PLoS ONE, 9(10): e110648-

2014

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Aguilar, Ximena
Blomberg, Jeanette
Brännström, Kristoffer; et al.

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors
PLoS ONE, 9(5): e98575-

2014

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Vincent, Andrea G
Vestergren, Johan
Gröbner, Gerhard; et al.

Soil organic phosphorus transformations in a boreal forest chronosequence
Plant and Soil, 367(1-2): 149-162

2013

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Clementi, Emily A.
Wilhelm, Kristina R.
Schleucher, Juergen; et al.

A Complex of Equine Lysozyme and Oleic Acid with Bactericidal Activity against Streptococcus pneumoniae
PLoS ONE, 8(11): Article Number: UNSP e80649-

2013

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Erhagen, Björn
Öquist, Mats
Sparrman, Tobias; et al.

Temperature response of litter and soil organic matter decomposition is determined by chemical composition of organic material
Global Change Biology, 19(12): 3858-3871

2013

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Chaintreau, Alain
Fieber, Wolfgang
Sommer, Horst; et al.

Site-specific C-13 content by quantitative isotopic C-13 nuclear magnetic resonance spectrometry: a pilot inter-laboratory study
Analytica Chimica Acta, 788: 108-113

2013

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Schleucher, Jürgen
Gröbner, Gerhard
Karlsson, Göran

NMR for LifeA national research infrastructure: a new NMR infrastructure provides access to world-class instruments for users from a wide range of research fields.
Kemivärlden biotech / kemisk tidskrift

2013

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Jürgen Schleucher

Contact Information

Umeå University
Medical Biochemistry and Biophysics
SE-901 87 Umeå, SWEDEN 

Visiting Address
KBC-building, 6th floor

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